Seagen

Senior Scientist Protein Mass Spectrometry Research

Research - Bothell, United States

Description

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Summary

We are looking for an energetic and experienced mass spectrometry scientist to join our Research Bioanalytical team in the Core Research and Technology department. This individual will help us grow our mass spectrometry capabilities, lead the development of new or improved techniques for the characterization of proteins and antibody drug conjugates in various matrices, as well as maintain our shared mass spectrometers. They will also participate in collaborative, cross-functional teams to enable cancer therapeutic development and aid in exploring scientific questions surrounding antibody-based therapeutic activity and behavior.

Principal Responsibilities:

• Determine and develop novel and appropriate LC-MS methods for the characterization of intact ADCs, antibodies, and other proteins.
• Develop and optimize both broadly applicable and fit-for-purpose methodologies for the capture, characterization, and quantification of proteins and conjugates from biological samples.
• Perform peptide mapping to deeply characterize proteins and bioconjugates.
• Provide care, maintenance, and troubleshooting of shared LC-MS instrumentation, including training new users and developing and maintaining best practices.
• Provide technical and scientific advice and support to scientists of all levels, advise on LC and mass spectrometry related questions, and provide sample processing and data analysis for non-MS users.
• Practice continuous improvement to refine methods and optimize processes, staying in touch with relevant literature and state of the art technologies.
• Maintain strong communication and collaborative relationships with mass spectrometry groups outside of Research.
• Create and organize technical information to deliver effective presentations in multiple forums

Required Qualifications:

• A Ph.D. or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with a recognized and established expertise in mass spectrometry.
• 4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas.
• Demonstrated experience in the operation and maintenance of mass spectrometers, their software, and applicable data analysis software.
• Established capability in biological characterization and data analysis, specifically utilizing mass spectrometry techniques.
• Attention to detail and a strong analytical mindset capable of proposing sound experimental strategies and developing new LC-MS protocols.
• Uses critical thinking to solve complex problems, address challenges, overcome obstacles, and anticipate areas for growth.
• Established safe laboratory skills and accurate record keeping.
• Ability to work independently on routine experiments.
• Ability to collaborate across teams and a variety of disciplines.
• Strong communication skills, both verbal and written.

Preferred Qualifications:

• Hands on experience working with a Waters Xevo G2S QTof, Thermofisher Q Exactive, and/or SCIEX X500B QTOF.
• Familiarity with affinity purification of proteins, peptides and/or metabolites.
• Experience analyzing all types of recombinant proteins.
• Experience identifying and characterizing post-translational modifications or enzymatic modifications of proteins.
• Experience with protein conformational analysis, such as Hydrogen deuterium exchange mass spectrometry.
• Familiarity with Protein Metrics software and reporting, including high throughput data processing.
• Experience or familiarity with mass spectrometry automation.
• Knowledge of SEC-MALS biological analysis methods.

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, visit www.seagen.com.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.

Apply:

Seagen

Seagen is an Equal Opportunity Employer

Submitted: 05/13/2022